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KMID : 0380519980020010025
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Korean Journal of Veterinary Pathology
1998 Volume.2 No. 1 p.25 ~ p.30
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Growth and metastasis of human malignant melanoma SK-MEL-2 cell line in SCID mice
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Choi Yang-Kyu
Choi Jae-Yoon
Jeon Hea-Sung
Won Young-Suk
Lee Chul-Ho
Yoon Won-Kee
Jeong Kyu-Shik
Lee Sang-Koo
Hyun Byung-Hwa
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Abstract
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An in vivo model for human melanoma was established with the growth and metastasis of SK-MEL-2 cells. The tumor was introduced into C.B-17 SCID(severe combined immunodeficiency) mice intraperiotneally subcutaeously and intravenous inoculations. Tumors developed in 100% of mice inoculated subcutaneously and intraeritoneally both at site of inoculation and as metastatic tumor in the liver lungs and diaphragm. With intravenous inoculation 50% of mice showed metastasis in the spleen. Additionally metastatic foci that were not detected either by gross and/or standard histopathologic examination were demonstrated in the spleen and lungs by immunohistochemistry with HMB-45 monoclonal antibody. We conclude that the SCID mouse supports growth and metastasis of human malignant melanoma SK-MEL-2 cells.
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KEYWORD
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immunohistochenistry, melanoma, metastasis, SCID, SK-MEL-2
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